Michel LAZDUNSKI

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Michel LAZDUNSKI

Scientific Board President

Michel Lazdunski is professor at the Medical School of the University of Nice – Sophia Antipolis He holds the chair of Molecular Pharmacology at the Institut Universitaire de France. A world-renowned specialist of ion channels, Michel Lazdunski has made internationally recognized contributions to basic research and to applied research in pharmacology and pathology. These range from understanding the mechanisms underlying oral antidiabetics, and inhalational anesthetics, to the mechanisms of pain perception, cardiac arrhythmia, epilepsy, depression, and cerebral ischemia.

Selected publications
Patents
Selected publications
M. Mazzuca, C. Heurteaux, A. Alloui, S. Diochot, A. Baron, N. Voilley, N. Blondeau, P. Escoubas, A. Grelot, A. Cupot, A. Zimmer, A.M. Zimmer, A. Eschalier, M. Lazdunski A tarantula peptide against pain via ASIC1a channels and opioid mechanisms Nat. Neurosci., 10, 943-945 2007
C. Heurteaux, G. Lucas, N. Guy, M. El Yacoubi, S. Thummler, X.D Peng, F. Noble, N. Blondeau, C. Widmann, M. Borsotto, G. Gobbi, J.M. Vaugeois, G. Debonnel, M. Lazdunski Deletion of the background potassium channel TREK-1 results in a depression resistant phenotype Nat. Neurosci., 9, 1134-1141 2006
A. Patel, E. Honoré, F. Lesage, M. Fink, G. Romey, M. Lazdunski Inhalational anaesthetics are activators of two pore domain background K+ channels Nat. Neurosci., 2, 422-426 1999
R. Waldmann, G. Champigny, F. Bassilana, C. Heurteaux, M. Lazdunski A proton gated cation channel involved in acid sensing Nature, 386, 173-177 1997
J. Barhanin, F. Lesage, E. Guillemare, M. Fink, M. Lazdunski, G. Romey KvLQT1 and IsK (minK) proteins associate to form the IKs cardiac potassium current Nature, 384, 78-80 1996
W. Dalemans, P. Barbry, G. Champigny, S. Jallat, K. Dott, D. DREYER, R. G. Crystal, A. Pavirani, J-P. Lcocq, M. Lazdunski Altered chloride ion channel kinetics associated with the F508 cyctic fibrosis mutation Nature, 354, 526-528 1991
S. Amoroso, H. Schmid-Antomarchi, M. Fosset, M. Lazdunski Glucose, sulfonylureas, and neurotransmitter release : role of ATP-sensitive K+ channels Science, 247, 852-854 1990
Patents