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PhD, Doctor in Neurosciences

Mélissa is Founder, President & Head of the In Vitro platform at E-PHY-SCIENCE. Trained as a neurophysiologist Mélissa has more than 10 years of experience in electrophysiology (Patch-Clamp and Field recording).

She received a PhD in Neurosciences from the ETH Zurich (Switzerland). She completed two post-doctoral fellowships in Switzerland, during which she was part of the Roche Program Fellowship.

Selected publications
Selected publications
Johannes Bohacek, Mélissa Farinelli, Osvaldo Mirante, Guyllaume Coiret, Guido Steiner, Martin Ebeling, Gonzalo Durán-Pacheco, A. Leonardo Iniguez, Francesca Manuella, Katharina Gapp, Jean-Luc Moreau and Isabelle M. Mansuy Pathological brain plasticity and cognition in the offspring of males subjected to postnatal traumatic stress. Molecular Psychiatry 2014
Melissa Farinelli*, FabriceHeitz*, Benjamin Grewe, Shiva Tyagarajan, FritjofHelmchen, Isabelle M. Mansuy. Protein phosphatase-1 activity promotes neuroprotection through modulation of NR2B-containing NMDA receptors. PloS One 2011
Mélissa Farinelli *, Anna Maria Calella, *, Mario Nuvolone, OsvaldoMirante,  Rita Moos, Isabelle Mansuy, Adriano Aguzzi Prion protein and Abeta-related synaptic toxicity impairment. EMBO Mol Med 2010
Kyoko Koshibu*, Johannes Gräff*, Monique Beullens, FabriceHeitz, DominikBerchtold, HolgerRussig, Mélissa Farinelli, Mathieu Bollen, and Isabelle M. Mansuy. Protein Phosphatase-1 Regulates the Histone Code for Long-term Memory. Journal of Neuroscience 2009
UrsulaHaditsch, Dino P. Leone, Mélissa Farinelli, Anna Chrostek-Grashoff, Cord Brakebusch, Isabelle M. Mansuy, Susan K. McConnell, Theo D. Palmer. A central role for the small GTPase Rac1 in hippocampal plasticity and spatial learning and memory. Molecular and Cellular Neuroscience 2009
Gaël F. Hédou*, Kyoko Koschibu*, Mélissa Farinelli,  ErtugrulKilic, UlkanKilic, Dirk M. Hermann, KarstenBaumgärtel,  and Isabelle M. Mansuy. PP1-dependent pathways and plasticity regulate the mechanisms of recovery in a mouse model of brain ischemia. Journal of Neuroscience 2008
Melissa Farinelli*, MarlenKnobloch* , UweKonietzko , Roger M. Nitsch and Isabelle M. Mansuy. Aß-oligomer mediated impairment of LTP is rescued by PP1 inhibition. Journal of Neuroscience 2007
Mélissa Farinelli, Olivier Deschaux, Sandrine Hugues, Aurélie Thevenet, and René Garcia. Hippocampal train stimulation modulates recall of fear extinction independently of prefrontal cortex synaptic plasticity and lesions. Learning and memory 2006
International Publication date: 31.07.2008
Use of phosphatase inhibitors for the treatment of neurodegenerative disease. WO2008/089961
Inventors: NITSCH Roger, KNOBLOCH, Marlen,  FARINELLI, Mélissa; MANSUY, Isabelle

International Publication date: 15.01.2009
Method of preventing and treating acute brain pathologies.. WO2009/007080
Inventors: FARINELLI, Mélissa; MANSUY, Isabelle, HEITZ Fabrice