Mélissa Farinelli

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Mélissa Farinelli, Founder and President of E-PHY-SCIENCE

PhD, Doctor in Neurosciences

Mélissa is Founder and President of E-PHY-SCIENCE.  Head of the Ex vivo platform, she was trained as a neurophysiologist and has more than 15 years of experience in Electrophysiology.

Mélissa completed a PhD in Neurosciences from the ETH Zurich (Switzerland). During her PhD, Mélissa performed fundamental discoveries on the mechanism underlying pro-death neuronal signaling pathways that contribute to neuronal degeneration in many acute CNS diseases. She then completed two post-doctoral fellowships in Switzerland, during which she was part of the Roche Program Fellowship. In the laboratory of Isabelle Mansuy (Brain Research Institute of Zurich) and in the lab of Kaspar Vogt (Biozentrum, university of Basel) Mélissa was trained as a neurophysiologist and has more than 15 years of experience in Electrophysiology.

As head of E-PHY-SCIENCE, over the last 8 years, Mélissa supervised several projects for pharma and biotech running CNS diseases programs.

Selected publications
Selected publications

Fanny Eysert, Audrey Coulon, Emmanuelle Boscher , Anaїs-Camille Vreulx, Amandine Flaig, Tiago Mendes , Sandrine Hugues , Benjamin Grenier-Boley, Xavier Hanoulle, Florie Demiautte, Charlotte Bauer, Mikael Marttinen, Mari Takalo, Philippe Amouyel, Shruti Desai, Ian Pike, Mikko Hiltunen, Frédéric Chécler, Mélissa Farinelli, Charlotte Delay, Nicolas Malmanche, Sébastien S Hébert, Julie Dumont, Devrim Kilinc, Jean-Charles Lambert, Julien Chapuis 

Alzheimer’s genetic risk factor FERMT2( Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner.

Molecular Psychiatry 2020

Michael Dumbacher, Tom Van Dooren, Katrien Princen, Koen De Witte, Mélissa Farinelli, Sam Lievens, Jan Tavernier, Wim Dehaen, Stefaan Wera, Joris Winderickx, Sara Allasia, Amuri Kilonda, Stéphane Spieser, Arnaud Marchand, Patrick Chaltin, Casper C. Hoogenraad, and Gerard Griffioen

Modifying Rap1-signalling by targeting Pde6δ is neuroprotective in models of Alzheimer’s disease


Molecular Neurodegeneration 2018

Fabrice D Heitz, Mélissa Farinelli, Safa Mohanna, Martin Kahn, Kerstin Duning, Marco C Frey, Hermann Pavenstädt, Isabelle M Mansuy 

The memory gene KIBRA is a bidirectional regulator of synaptic and structural plasticity in the adult brain.


Neurobiology of Learning and Memory 2016
Johannes Bohacek, Mélissa Farinelli, Osvaldo Mirante, Guyllaume Coiret, Guido Steiner, Martin Ebeling, Gonzalo Durán-Pacheco, A. Leonardo Iniguez, Francesca Manuella, Katharina Gapp, Jean-Luc Moreau and Isabelle M. Mansuy Pathological brain plasticity and cognition in the offspring of males subjected to postnatal traumatic stress. Molecular Psychiatry 2015
Melissa Farinelli*, Fabrice Heitz*, Benjamin Grewe, Shiva Tyagarajan, FritjofHelmchen, Isabelle M. Mansuy.

Selective Regulation of NR2B by Protein Phosphatase-1 for the Control of the NMDA Receptor in Neuroprotection

PloS One 2012
Mélissa Farinelli *, Anna Maria Calella, *, Mario Nuvolone, OsvaldoMirante,  Rita Moos, Isabelle Mansuy, Adriano Aguzzi Prion protein and Abeta-related synaptic toxicity impairment. EMBO Mol Med 2010
Kyoko Koshibu*, Johannes Gräff*, Monique Beullens, FabriceHeitz, DominikBerchtold, HolgerRussig, Mélissa Farinelli, Mathieu Bollen, and Isabelle M. Mansuy. Protein Phosphatase-1 Regulates the Histone Code for Long-term Memory. Journal of Neuroscience 2009
Ursula Haditsch, Dino P. Leone, Mélissa Farinelli, Anna Chrostek-Grashoff, Cord Brakebusch, Isabelle M. Mansuy, Susan K. McConnell, Theo D. Palmer. A central role for the small GTPase Rac1 in hippocampal plasticity and spatial learning and memory. Molecular and Cellular Neuroscience 2009
Gaël F. Hédou*, Kyoko Koschibu*, Mélissa Farinelli,  ErtugrulKilic, UlkanKilic, Dirk M. Hermann, KarstenBaumgärtel,  and Isabelle M. Mansuy. Protein Phosphatase 1-Dependent Bidirectional Synaptic Plasticity Controls Ischemic Recovery in the Adult Brain. Journal of Neuroscience 2008
Melissa Farinelli*, MarlenKnobloch* , UweKonietzko , Roger M. Nitsch and Isabelle M. Mansuy. Aβ Oligomer-Mediated Long-Term Potentiation Impairment Involves Protein Phosphatase 1-Dependent Mechanisms Journal of Neuroscience 2007
Mélissa Farinelli, Olivier Deschaux, Sandrine Hugues, Aurélie Thevenet, and René Garcia. Hippocampal train stimulation modulates recall of fear extinction independently of prefrontal cortex synaptic plasticity and lesions. Learning and memory 2006
International Publication date: 31.07.2008
Use of phosphatase inhibitors for the treatment of neurodegenerative disease. WO2008/089961
Inventors: NITSCH Roger, KNOBLOCH, Marlen,  FARINELLI, Mélissa; MANSUY, Isabelle

International Publication date: 15.01.2009
Method of preventing and treating acute brain pathologies.. WO2009/007080
Inventors: FARINELLI, Mélissa; MANSUY, Isabelle, HEITZ Fabrice