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E PHY SCIENCE In Vivo Ex Vivo Electrophysiology platform

Tail Suspension

Goal: depression

Principle: the animal is suspended above the ground by their tails with tape, in such a position that it cannot escape or hold on to nearby surfaces. Animals, subjected to an inescapable stress, innately attempt to escape from this adversive situation. Following failed attempts to escape, they experience a kind of despair and adopt an immobile posture. A high level of immobility will be characteristic of a depressive-like state.